merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB290F,Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

  • merck millipore,默克密理博,FCMAB290F,Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

    产品名称：Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4
    产品型号：FCMAB290F
    This Milli-Mark Anti-GluR2-FITC Antibody, clone 6C4 is validated for use in FC for the detection of GluR2.

    merck millipore,默克密理博,FCMAB290F,Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

  • 产品介绍
  • merck millipore,默克密理博,FCMAB290F,Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB290F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4
    Alternate Names
    • glutamate receptor 2
    背景信息 Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this positionis occupied by a Gln residue. In GluR2, it is occupied by an Arg residue. It has been shown experimentally that the presence of Arg in this position blocks CA2+ ion permeability, while a Gln does not. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.
    产品信息
    格式 FITC
    控制
    • U251 cells
    演示 Purified mouse monoclonal IgG2a conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 This Milli-Mark Anti-GluR2-FITC Antibody, clone 6C4 is validated for use in FC for the detection of GluR2.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Recombinant fusion protein TrpE-GluR2 (putative N-terminal portion, amino acids 175-430).
    克隆 6C4
    宿主 Mouse
    特异性 Antibody recognizes Glutamate Receptor 2.
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001077280
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.
    基因符号
    • GluR-K2
    • Gria2
    • GLUR2
    • GLURB
    • GluR-2
    • GluR-B
    纯化方法 Protein A Purified
    UniProt编号
    • P19491
    UniProt汇总 FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

    SIZE: 883 amino acids; 98,688 Da

    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4(By similarity). Interacts with CACNG2, PRKCABP, GRIP1 and GRIP2. Interacts with NSF via its C-terminus. Part of a complex containing GRIA2, NSF and NAPA and/or NAPB.

    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note= Interaction with CACNG2 promotes cell surface expression.

    TISSUE SPECIFICITY: Detected in forebrain. Detected in dendrites of neuronal cells.

    SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family
    产品使用声明
    质量保证 Evaluated by flow cytometry using U251 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB290F,Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

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