merck millipore,默克密理博,FCMAB227F,Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC	Ht	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB227F
商名	Milli-Mark
描述	Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11
Alternate Names	CD3e T-cell surface glycoprotein CD3 epsilon chain T-cell surface antigen T3/Leu-4 epsilon chain
背景信息	Human TCR/CD3 is a complex structure on the lymphocyte surface. It consists of the TCR alpha beta or TCR gamma delta heterodimer and the associated CD3 complex. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon. and zeta. Three different dimers, gamma epsilon, delta epsilon, and zeta zeta, constitute the CD3 complex. The MW of CD3epsilon is 20 000 (Campana, 1987). CD3 is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface (Swerdlow, 1988; Beverley, 1981). The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies (McMichael, 1987). Consistent with the pattern of synthesis of the antigen in normal thymocytes, the earliest site detectable within neoplastic cells is the cell cytoplasm (Swerdlow, 1988).

产品信息
格式	FITC
控制	Mouse splenocytes
演示	Purified hamster monoclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	This Milli-Mark Anti-mouse CD3-FITC Antibody, clone 145-2C11 is validated for use in FC for the detection of mouse CD3.
主要应用	Flow Cytometry

生物信息
免疫原品种	Animals were immunized with the BM10-37 mouse cytotoxic T lymphocyte (CTL) cell clone (anti H-2 Kb). Spleen cells were fused with Sp2/0-Ag14 myeloma cells.
克隆	145-2C11
宿主	Hamster
特异性	Antibody recognizes CD3 epsilon chain.
同种型	IgG
品种反应性	Mouse
Species Reactivity Note	Tested and passed on Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_031674.1.
基因符号	Cd3e
纯化方法	Protein G Purified
UniProt编号	P22646
UniProt汇总	FUNCTION: The CD3 complex mediates signal transduction. SUBUNIT STRUCTURE: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SEQUENCE SIMILARITIES: Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 ITAM domain.

产品使用声明
质量保证	Evaluated by flow cytometry using mouse splenocytes
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB227F,Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11

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