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品种反应性 主要应用 宿主 格式 抗体类型 R IHC Gp Serum Polyclonal Antibody 描述 产品目录编号 AB10556 描述 Anti-mGluR8 Antibody Alternate Names - metabotropic 8
- glutamate metabotropic receptor 8
- glutamate receptor
背景信息 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. 产品信息 格式 Serum 控制 - Rat brain lysate
演示 Unpurified guinea pig polyclonal serum with 0.05% sodium azide. 应用 应用 Anti-mGluR8 Antibody detects level of mGluR8 & has been published & validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Evaluated by Western Blot in rat brain lysate. Although intended for use in IHC analysis, a band was observed at ~101kDa. 生物信息 免疫原品种 This antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8. 表位 Cytoplasmic Domain 宿主 Guinea Pig 特异性 This antibody recognizes mGluR8. 品种反应性 Rat Species Reactivity Note Predicted to react with human, chimpanzee, monkey, dog, cow and mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000836.2
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. 基因符号 - GRM8
- GLUR8
- mGlu8
- GPRC1H
- MGLUR8
- FLJ41058
- MGC126724
纯化方法 Unpurified UniProt编号 - O00222
UniProt汇总 FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
SUBUNIT STRUCTURE: Interacts with PICK1 By similarity.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family.产品使用声明 质量保证 Immunohistochemistry Analysis: : 1:100-500 dilution from a previous lot detected mGluR8 on rat brain tissue. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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