merck millipore,默克密理博,FCMAB122F,Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB122F
商名	Milli-Mark
描述	Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate
Alternate Names	JNK1 alpha protein kinase <br />JNK1 beta protein kinase <br />JUN N-terminal kinase <br />Stress-activated protein kinase JNK1 <br />c-Jun N-terminal kinase 1 <br />mitogen-activated protein kinase 8 <br />mitogen-activated protein kinase 8 isoform JNK1 alpha1 <br />mitogen-activated protein kinase 8 isoform JNK1 beta2 <br />protein kinase JNK1
背景信息	c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.

产品信息
格式	FITC
控制	NIH/3T3 cells
演示	Purified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用

Milli-Mark Anti-c-Jun Antibody, clone 6E4, FITC Conjugate is an antibody against c-Jun for use in FC.

主要应用

应用说明

Working Solution	Cells / test	Total Reaction Volume
5 μl	5 x 10⁵ Cells / 95 μl PBS	100 μl
10 μl	1 x 10⁶ Cells / 90 μl PBS	100 μl

生物信息
免疫原品种	GST-tagged recombinant protein corresponding to c-Jun.
克隆	6E4
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Antibody recognizes c-Jun. .
同种型	IgG1κ
品种反应性	RatHumanMouse
Species Reactivity Note	Tested and passed on Mouse. Unconjugated antibody shown to work in Human, Mouse and Rat using ICC.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002219.1
Entrez基因汇总	This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involvedin both translocations and deletions in human malignancies.
基因符号	SAPK1 EC 2.7.11.24 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 OTTHUMP00000019552 OTTHUMP00000019555 OTTHUMP00000019556 OTTHUMP00000019558 PRKM8
纯化方法	Protein G purfied
UniProt编号	P45983
UniProt汇总	FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4).

产品使用声明
质量保证	Evaluated by flow cytometry using NIH/3T3
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB122F,Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

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