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merck millipore,默克密理博,05-637,Anti-Bmi-1 Antibody, clone F6
产品名称：Anti-Bmi-1 Antibody, clone F6
产品型号：05-637
Anti-Bmi-1 Antibody, clone F6 is a Mouse Monoclonal Antibody for detection of Bmi-1 also known as Polycomb group RING finger protein 4, RING finger protein 51 & has been validated in ICC, IP & WB.
merck millipore,默克密理博,05-637,Anti-Bmi-1 Antibody, clone F6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-637 品牌系列 Upstate
商名 - Upstate
描述 Anti-Bmi-1 Antibody, clone F6 Alternate Names - RING finger protein 51
- Polycomb group RING finger protein 4
背景信息 The Bmi1 protein is a member of the polycomb group (PcG) proteins. PcG proteins form multiprotein complexes that function as transcriptional repressors.
Several lines of evidence implicate Bmi1 in tumorigenesis. Firstly, Bmi1 cooperates with c-Myc in the generation of lymphomas in double transgenic mice. Secondly, Bmi1 blocks senescence and immortalizes mouse embryo fibroblasts, although not human fibroblasts, and in combination with an activated H-ras gene leads to neoplastic transformation. Thirdly, the BMI1 gene is amplified in certain mantle cell lymphomas and is overexpressed in a subset of non-small cell lung cancer, colorectal carcinomas, multiple myelomas and medulloblastomas, but not glioblastomas. Fourthly, the transformation of human hematopoietic progenitor cells by the oncogenic fusion protein E2a-Pbx1 requires Bmi1. Indeed, based on a list of genes differentially expressed in a mouse model of metastatic prostate cancer on a wild-type and bmi1-deficient genetic background a gene signature was recently identified that may predict response to therapy and survival in multiple types of cancer.产品信息 格式 Purified 控制 - U2OS whole cell lysate, K-562 nuclear extract, 0-4 hour embryos or 12-24 hour embryos
演示 Immunoaffinity Purified immunoglobulin in Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH 7.4. 应用 应用 Anti-Bmi-1 Antibody, clone F6 is a Mouse Monoclonal Antibody for detection of Bmi-1 also known as Polycomb group RING finger protein 4, RING finger protein 51 & has been validated in ICC, IP & WB. 主要应用 - Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 Immunized with recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1. 克隆 F6 宿主 Mouse 特异性 Recognizes Bmi-1 (triplet). 同种型 IgG1 品种反应性 RabbitHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005180
基因符号 - PCGF4
- flvi-2/bmi-1
- RNF51
- BMI1
- MGC12685
纯化方法 Protein G purfied UniProt编号 - P25916
- P35226
UniProt汇总 FUNCTION: SwissProt: P35226 # Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
SIZE: 326 amino acids; 36949 Da
SUBUNIT: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1- like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP.
SUBCELLULAR LOCATION: Nucleus.
PTM: May be polyubiquitinated; which does not lead to proteasomal degradation.DISEASE:SwissProt: P35226 # Cooperates with the MYC oncogene to produce B-lymphomas.
SIMILARITY: SwissProt: P35226 ## Contains 1 RING-type zinc finger.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from U2OS cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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