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merck millipore,默克密理博,553014,Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem
产品名称：Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem
产品型号：553014
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>
merck millipore,默克密理博,553014,Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₄ClN₃O 303727-31-3 描述 概述 A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf. 产品目录编号 553014 品牌系列 Calbiochem®
同义词 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450 参考 参考 Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
Shelton, J.G., et al. 2003. Leukemia 17, 1765.产品信息 CAS号 303727-31-3 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₂₀H₁₄ClN₃O 化学配方 C₂₀H₁₄ClN₃O Molar Mass 347.8 可逆 Y 结构配方图像 生物信息 主靶 Raf Kinase 主靶IC50 10 nM; Kd = 2.4 nM for B-raf 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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