- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,FCMAB112F,Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate
产品名称：Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate
产品型号：FCMAB112F
Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate is an antibody against SOX-2 for use in FC.
merck millipore,默克密理博,FCMAB112F,Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB112F 描述 Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate Alternate Names - SRY (sex determining region Y)-box 2
- SRY-related HMG-box gene 2
- sex-determining region Y-box 2
- transcription factor SOX2
背景信息 Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. 产品信息 格式 FITC 控制 - Rat Neural Stem Cells.
演示 Purified mouse monoclonal IgG2b conjugated to FITC in PBS with less than 0.09% sodium azide and 15 mg/mL BSA. 应用 应用 Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate is an antibody against SOX-2 for use in FC. 主要应用 - Flow Cytometry
应用说明 Flow Cytometry:
Antibody dilution for cellular staining:
• Prepare an antibody working solution by diluting 1:5 the primary antibody with PBS.
• Dispense the volume per test of working of solution according to the number of cells indicated in the table below.
• 5 µL for Guava Flow Cytometer
• 10 µL for other Flow Cytometry instruments
Working Solution Cells / test Total Reaction Volume 5 μl 5 x 105 Cells / 95 μl PBS 100 μl 10 μl 1 x 106 Cells / 90 μl PBS 100 μl 生物信息 免疫原品种 Recombinant GST Fusion protein. 克隆 6G1.2 宿主 Mouse 特异性 SOX-2 同种型 IgG2b 品种反应性 RatHumanMouse Species Reactivity Note Tested and passed on Human. based on 100% sequence homology. Human and Rat 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003097.1
Entrez基因汇总 This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript
(SOX2OT).基因符号 - MGC2413
- ANOP3
- MCOPS3
纯化方法 Protein A purfied UniProt编号 - P48431
UniProt汇总 FUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency By similarity.
SUBCELLULAR LOCATION: Nucleus.
PTM: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation By similarity.
INVOLVEMENT IN DISEASE: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
SEQUENCE SIMILARITIES: Contains 1 HMG box DNA-binding domain.产品使用声明 质量保证 Evaluated by flow cytometry on undifferentiated adult Rat hippocampal neural stem cells SCR022.
Optimal working dilutions must be determined by the end user.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8oC protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
上一件merck millipore产品：merck millipore,默克密理博,565749,β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,616399,Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem
相关产品
merck millipore,默克密理博,07-612,Anti-Peroxiredoxin 4 Antibody
merck millipore,默克密理博,MABT129,Anti-VE-Cadherin Antibody (CD144), clone BV9
merck millipore,默克密理博,SF-901,Vimentin; Human, Cyanine 3, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,101543,精胺酸盐酸盐
merck millipore,默克密理博,565749,β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem
merck millipore,默克密理博,616399,Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem
merck millipore,默克密理博,07-1219,Anti-PP2A Antibody, B β subunit
merck millipore,默克密理博,5202,L-Phenylalanine - CAS 63-91-2 - Calbiochem
merck millipore,默克密理博,ABN67,Anti-AIF-1 Antibody
merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem