merck millipore,默克密理愽
  • merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

  • merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

    产品名称：Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
    产品型号：178494
    The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₀ClF₃N₂O₃426834-38-0
    描述
    概述 A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
    产品目录编号 178494
    品牌系列 Calbiochem®
    同义词 NS3694
    参考
    参考 Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
    产品信息
    CAS号 426834-38-0
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₅H₁₀ClF₃N₂O₃
    化学配方 C₁₅H₁₀ClF₃N₂O₃
    Molar Mass 358.7
    可逆 N
    结构配方图像
    生物信息
    主靶 Apoptosome complex formation
    主靶IC50 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

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