- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Ma WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1491 Replaces AB1695 描述 Anti-Calcineurin pan A Antibody Alternate Names - serine/threonine-protein phosphatase 2B catalytic subunit<br />alpha isoform
- CAM-PRP catalytic subunit
- Calmodulin-dependent calcineurin A subunit alpha isoform
- calcineurin A alpha
- protein phosphatase 3 (formerly 2B), catalytic subunit,<br />alpha isoform
- protein phosphatase 3 (formerly 2B), catalytic subunit,<br />alpha isoform (calcineurin A alpha)
- protein phosphatase 3, catalytic subunit, alpha isoform
背景信息 Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling. 产品信息 格式 Affinity Purified 控制 - Mouse brain lysate
演示 Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative. 应用 应用 Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to Calcineurin. 宿主 Rabbit 特异性 This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species. 品种反应性 Mammals Species Reactivity Note Reacts with human, mouse, and rat. Predicted to react with all mammals based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000935.1
基因符号 - PPP2B
- CALN
- CALNA
- CALNA1
- CCN1
- CNA
- CNA1
- EC 3.1.3.16
纯化方法 Affinity Purfied UniProt编号 - Q08209
UniProt汇总 FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.
CATALYTIC ACTIVITY: A phosphoprotein + H2O = a protein + phosphate.
COFACTOR:Binds 1 Fe3+ ion per subunit.
Binds 1 zinc ion per subunit.
SUBUNIT STRUCTURE: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.
SUBCELLULAR LOCATION: Nucleus By similarity. Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle By similarity.
SEQUENCE SIMILARITIES: Belongs to the PPP phosphatase family. PP-2B subfamily.产品使用声明 质量保证 Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.
包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,420321,KT5823 - CAS 126643-37-6 - Calbiochem
相关产品
merck millipore,默克密理博,616399,Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem
merck millipore,默克密理博,07-1219,Anti-PP2A Antibody, B β subunit
merck millipore,默克密理博,5202,L-Phenylalanine - CAS 63-91-2 - Calbiochem
merck millipore,默克密理博,ABN67,Anti-AIF-1 Antibody
merck millipore,默克密理博,178494,Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
merck millipore,默克密理博,420321,KT5823 - CAS 126643-37-6 - Calbiochem
merck millipore,默克密理博,GF307,β-NGF Protein, Human Recombinant Animal Free
merck millipore,默克密理博,SCM045,Human Mesenchymal-XF Expansion Medium
merck millipore,默克密理博,SF-2484,HOXA1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
