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merck millipore,默克密理博,FCMAB100P,Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE
产品名称：Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE
产品型号：FCMAB100P
This Milli-Mark Phospho-Erk1/2 antibody is validated for use in Flow & WB for the detection of the Milli-Mark Phospho-Erk1/2 protein.
merck millipore,默克密理博,FCMAB100P,Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE
- 产品介绍
- merck millipore,默克密理博,FCMAB100P,Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, FC Rb PE Polyclonal Antibody 描述 产品目录编号 FCMAB100P 商名 - Milli-Mark
描述 Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE Alternate Names - Erk1 <br />Erk2 <br />p44-MAPK <br />p42-MAPK <br />MAPK2 <br />PRKM2 <br />p41mapk <br />PRKM1 <br />p44 <br />ERK2 <br />P42MAPK <br />ERK <br />p42 <br />MAPK1 <br />ERT1 <br />ERT2 <br />Mitogen-activated protein kinase <br />MAP Kinase 2 <br />MAP Kianse 1 <br />MAPK
背景信息 Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted as Erk1 (p44, MAPK3) and Erk2 (p42, MAPK1) that both function in the same pathway. The two proteins are often referred to collectively as Erk1/2 or p44/p42 MAP kinase. The Erk pathway is considered the classical, canonical MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It is an evolutionarily conserved pathway that controls and is a critical regulator of the growth and survival through the promotion of cell proliferation and the prevention of apoptosis. Erk is involved in the control of many fundamental cellular processes including cell proliferation, survival, differentiation, apoptosis, motility and metabolism. Erk is activated by growth factor stimulation of receptor tyrosine kinases (RTKs), GPCR, and/or integrin stimulation. This activates the Ras-Raf-MEK-Erk pathway that results in the phosphorylation/activation of Erk1/2 (p44/p42) on the TxY motif (Thr202/Tyr204 and Thr185/Tyr187 for Erk1 & Erk2, respectively). 产品信息 格式 PE 控制 - Jurkat Cells
演示 Purified Rabbit monoclonal supernatant conjugated to phycoerythrin in buffer containing PBS with 0.05% sodium azide 应用 应用 This Milli-Mark Phospho-Erk1/2 antibody is validated for use in Flow & WB for the detection of the Milli-Mark Phospho-Erk1/2 protein. 主要应用 - Western Blotting
- Flow Cytometry
生物信息 免疫原品种 Phosphorylated recombinant peptide corresponding to amino acids surrounding the pTEpY motif in the activation loop of human phospho-Erk1/2, in which the Thr and Tyr residues are phosphorylated 表位 Phosphorylated Thr185/Phosphorylated Tyr187 克隆 AW39R 宿主 Rabbit 特异性 Antibody recognizes Recognizes Erk 1 & 2 only when dually phosphorylated on its TxY activation motif. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Tested and passed on Human. based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002736.3
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. 基因符号 - MAPK
- Erk1
- Erk2
- p44-MAPK
- p42-MAPK
- MAPK2
- PRKM2
- p41mapk
- PRKM1
- p44
- ERK2
- P42MAPK
- ERK
- p42
- MAPK1
- ERT1
- ERT2
- Mitogen-activated protein kinase
- MAP Kinase 2
- MAP Kinase 1
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - P28482
UniProt汇总 FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
COFACTOR: Magnesium (By similarity).
SIZE: 360 amino acids; 41390 Da
SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by Flow Cytometry with Jurkat cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at 2-8°C from date of receipt. Protect from light. 包装信息 数量 100 tests
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