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品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL517 Replaces CBL517P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD28 Antibody, clone 15E8 Alternate Names - Tp44
产品信息 格式 Purified 演示 Please see lot specific datasheet for product formulation. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 This Anti-CD28 Antibody, clone 15E8 is validated for use in FC, FUNC for the detection of CD28. 主要应用 - Flow Cytometry
应用说明 To study the role of CD28 in T cell proliferation. The antibody will induce the proliferation of resting T lymphocytes.
This antibody will act in cell stimulation studies where it has been suggested that measuring T cell function in HIV infected asymptomatic patients may be an early indicator of AIDS, independent of CD4 + cell counts
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human T lymphocytes 克隆 15E8 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody reacts with the 44 kDa antigen found on a sub-population of T cells and activated B cells. These CD28+ CD8 cells are now known to be cytotoxic T cell precursors. The antibody does not react with B cells, granulocytes or monocytes. The ligand for CD28 is CD80 (B7) which is found on activated B cells suggesting a role for CD28 in T and B cell interaction
FUSION PARTNER: SP2/0同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006139.1
Entrez基因汇总 CD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM] 基因符号 - MGC138290
- CD28
- Tp44
- TP44
非反应性品种 - Canine
UniProt编号 - P10747
UniProt汇总 FUNCTION: SwissProt: P10747 # Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
SIZE: 220 amino acids; 25066 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in T-cells and plasma cells, but not in less mature B-cells.
SIMILARITY: SwissProt: P10747 ## Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,FCMAB124A4,Milli-Mark™ Anti-mOCT4 Antibody, clone 7F9.2, Alexa Fluor 488 Conjugate
下一件merck millipore产品：merck millipore,默克密理博,AB2039,Anti-Elastin Antibody
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