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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R IHC, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2039 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Elastin Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 0.01M phosphate, 0.09M NaCl, pH7.2 with no preservatives. 应用 应用 This Anti-Elastin Antibody is validated for use in ELISA, RIA, IH for the detection of Elastin. 主要应用 - Immunohistochemistry
- ELISA
应用说明 Immunohistochemistry: 1:40 dilution for immunofluorescent staining of frozen rat skin and liver tissues.
Radioimmunoassay
ELISA: 1:100-1:200
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Elastin extracted and purified from rat aorta. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Antibody shows less than 0.1% reactivity with rat Collagen Types I, II, III, V and human Elastin by radioimmunoassay. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001081755.1
- NM_000501.2
- NM_001081752.1
- NM_001081753.1
- NM_001081754.1
Entrez基因汇总 This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. 基因符号 - WBS
- ELN
- tropoelastin
- FLJ38671
- SVAS
- WS
- Tropoelastin
- elastin
- FLJ43523
UniProt编号 - P15502
UniProt汇总 FUNCTION: SwissProt: P15502 # Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
SIZE: 786 amino acids; 68499 Da
SUBUNIT: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.
TISSUE SPECIFICITY: Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.
PTM: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. & Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates (By similarity).
DISEASE: SwissProt: P15502 # Defects in ELN are a cause of autosomal dominant cutis laxa [MIM:123700]. Cutis laxa is a rare connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. The skin changes are often accompanied by extracutaneous manifestations, including pulmonary emphysema, bladder diverticula, pulmonary artery stenosis and pyloric stenosis. & Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder and a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. & Defects in ELN are the cause of supravalvular aortic stenosis (SVAS) [MIM:185500]. SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome.
SIMILARITY: SwissProt: P15502 ## Belongs to the elastin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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