merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL1348,Anti-Integrin beta1 Antibody, clone HM beta 1.1

  • merck millipore,默克密理博,CBL1348,Anti-Integrin beta1 Antibody, clone HM beta 1.1

    产品名称：Anti-Integrin beta1 Antibody, clone HM beta 1.1
    产品型号：CBL1348
    Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.

    merck millipore,默克密理博,CBL1348,Anti-Integrin beta1 Antibody, clone HM beta 1.1

  • 产品介绍
  • merck millipore,默克密理博,CBL1348,Anti-Integrin beta1 Antibody, clone HM beta 1.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICCHtPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL1348
    描述 Anti-Integrin beta1 Antibody, clone HM beta 1.1
    Alternate Names
    • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen<br />CD29 includes MDF2, MSK12)
    • CD29 antigen
    • Fibronectin receptor subunit beta
    • Integrin VLA-4 subunit beta
    • fibronectin receptor beta subunit
    • integrin VLA-4 beta subunit
    • integrin beta 1
    • integrin
    • beta 1 (fibronectin receptor
    • beta polypeptide
    • antigen<br />CD29 includes MDF2
    背景信息 Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.
    产品信息
    格式 Purified
    控制
    • NIH3T3, A431
    演示 Purified in PBS with 0.05% NaN3.
    应用
    应用 Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
    主要应用
    • Immunocytochemistry
    生物信息
    免疫原品种 Purified mouse VLA-4 antigen
    表位 Full length
    克隆 HM beta 1.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Hamster
    同种型 IgG
    品种反应性 MouseHuman
    Species Reactivity Note Reacts with mouse and human. Other species have not been tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002202.2
    Entrez基因汇总 Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq]
    基因符号
    • VLAB
    • CD29
    • FNRB
    • GPIIA
    • MDF2
    • MSK12
    • OTTHUMP00000019420
    • OTTHUMP00000046253
    • OTTHUMP00000063731
    • OTTHUMP00000063732
    • OTTHUMP00000063733
    • VLA-BETA
    纯化方法 Protein G purfied
    UniProt编号
    • P09055
    UniProt汇总 FUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA, FLNB, FLNC and RANBP9. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity).
    LOCATION: Membrane; Single-pass type I membrane protein. Melanosome (By similarity).
    SIMILARITY: Belongs to the integrin beta chain family.
    SIMILARITY: Contains 1 VWFA domain.
    产品使用声明
    质量保证 Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL1348,Anti-Integrin beta1 Antibody, clone HM beta 1.1

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