merck millipore,默克密理愽
  • merck millipore,默克密理博,05-406,Anti-JAK3 Antibody, clone B32-32

  • merck millipore,默克密理博,05-406,Anti-JAK3 Antibody, clone B32-32

    产品名称：Anti-JAK3 Antibody, clone B32-32
    产品型号：05-406
    Anti-JAK3 Antibody, clone B32-32 detects level of JAK3 & has been published & validated for use in IP.

    merck millipore,默克密理博,05-406,Anti-JAK3 Antibody, clone B32-32

  • 产品介绍
  • merck millipore,默克密理博,05-406,Anti-JAK3 Antibody, clone B32-32

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIPMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-406
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-JAK3 Antibody, clone B32-32
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
    应用
    应用 Anti-JAK3 Antibody, clone B32-32 detects level of JAK3 & has been published & validated for use in IP.
    主要应用
    • Immunoprecipitation
    应用说明 Not recommended for WB.
    生物信息
    免疫原品种 GST-fusion protein containing amino acids 1076-1100 of murine thymus JAK3. Clone B32-32.
    克隆 B32-32
    宿主 Mouse
    特异性 JAK3
    同种型 IgG2bκ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000215
    Entrez基因汇总 JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease).
    基因符号
    • JAK3_HUMAN
    • JAK3
    • LJAK
    • L-JAK
    • JAK-3
    • JAKL
    纯化方法 Protein A chromatography
    UniProt编号
    • P52333
    UniProt汇总 FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.
    SIZE: 1124 amino acids; 125099 Da
    SUBUNIT: Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.
    SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).
    TISSUE SPECIFICITY: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.
    DOMAIN: SwissProt: P52333 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
    PTM: Tyrosine phosphorylated in response to IL-2 and IL-4.
    DISEASE: SwissProt: P52333 # Defects in JAK3 are a cause of autosomal recessive T-cell negative/B-cell positive type of severe combined immunodeficiency (SCID) [MIM:600802]; a condition characterized by the absence of circulating mature T-lymphocytes and NK cells, normal to elevated numbers of nonfunctional B-lymphocytes, and marked hypoplasia of lymphoid tissues.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoprecipitation of JAK3 from CTLL cells or from TF-1 RIPA cell lysate
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-406,Anti-JAK3 Antibody, clone B32-32

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