merck millipore,默克密理愽
  • merck millipore,默克密理博,AG305,Glutamate Receptor 2 & 3, control peptide for AB1506

  • merck millipore,默克密理博,AG305,Glutamate Receptor 2 & 3, control peptide for AB1506

    产品名称：Glutamate Receptor 2 & 3, control peptide for AB1506
    产品型号：AG305


    merck millipore,默克密理博,AG305,Glutamate Receptor 2 & 3, control peptide for AB1506

  • 产品介绍
  • merck millipore,默克密理博,AG305,Glutamate Receptor 2 & 3, control peptide for AB1506

    描述
    产品目录编号 AG305
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Glutamate Receptor 2 & 3, control peptide for AB1506
    概述 Peptide from the carboxy terminus of rat GluR2.
    Alternate Names
    • GluR2/3
    产品信息
    演示 Liquid in water. Contains no preservative.
    应用
    主要应用
    • Cell Function Assay
    应用说明 For use in blocking the reactivity of AB1506.

    Optimal working dilution must be determined by the end user.
    生物信息
    浓缩 1.0 mg/mL
    品种 Rat
    Entrez基因编号
    • NM_001083620.1
    • NM_000826.3
    • NM_001083619.1
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
    基因符号
    • GLURB
    • GRIA2
    • GluR-B
    • gluR-B
    • GluR-2
    • HBGR2
    • GluR-K2
    • GLUR2
    UniProt编号
    • P42262
    UniProt汇总 FUNCTION: SwissProt: P42262 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
    SIZE: 883 amino acids; 98821 Da
    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
    SIMILARITY: SwissProt: P42262 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AG305,Glutamate Receptor 2 & 3, control peptide for AB1506

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