merck millipore,默克密理愽
  • merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

  • merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

    产品名称：IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem
    产品型号：401487
    The IKK-2 Inhibitor VIII, also referenced under CAS 406208-42-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₂₄N₄O₂406208-42-2
    描述
    概述 A cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC50 = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC50 >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC50 <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
    产品目录编号 401487
    品牌系列 Calbiochem®
    同义词 2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP
    参考
    参考 Murata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.
    产品信息
    CAS号 406208-42-2
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₂₁H₂₄N₄O₂
    化学配方 C₂₁H₂₄N₄O₂
    Molar Mass 364.4
    可逆 N
    结构配方图像
    生物信息
    主靶 IKK-2
    主靶IC50 8.5 and 250 nM for IKK-2 and IKK-1, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

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