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merck millipore,默克密理博,AB5604-200UL,Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type
产品名称：Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type
产品型号：AB5604-200UL
Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type detects level of Calcium Channel & has been published & validated for use in WB.
merck millipore,默克密理博,AB5604-200UL,Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5604-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type Alternate Names - Cacna2d1
产品信息 格式 Affinity Purified 控制 - CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 0.75 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 L of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type detects level of Calcium Channel & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:200 using ECL on rat brain membranes.
Dilutions should be made using a carrier protein such as BSA (1-3%)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Peptide corresponding to 15 amino acids from the rabbit alpha2 subunit (residues 27-41 of rabbit alpha2/delta-1 precursor) P13806 表位 Voltage Gated alpha 2/delta-1,L-type 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes alpha2/delta-1 subunit, N-terminal. The epitope does not share homology with any other known proteins. By sequence comparsions, the epitope sequence used is identical in human, porcine, with mouse and rat missing only a single amino acid. Reactivity has been verified only in rat membranes. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000722.2
Entrez基因汇总 This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. 基因符号 - WUGSC:H_DJ0560O14.1
- CACNA2D1
- CACNA2
- CACNL2A
- H_DJ0560O14.1
- CCHL2A
- MHS3
UniProt编号 - P54289
UniProt汇总 FUNCTION: SwissProt: P54289 # The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
SIZE: 1091 amino acids; 123183 Da
SUBUNIT: Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Central nervous system, skeletal muscle and aorta tissues.
DOMAIN: SwissProt: P54289 The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity).
PTM: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By similarity).
SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta family. & Contains 1 cache domain. & Contains 1 VWFA domain.
MISCELLANEOUS: Binds gabapentin, an antiepileptic drug.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,401487,IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem
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