merck millipore,默克密理愽
  • merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

  • merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

    产品名称：SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem
    产品型号：565851
    The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & D More>>

    merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₁N₃Na₂O₇S₂56932-43-5
    描述
    概述 A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
    产品目录编号 565851
    品牌系列 Calbiochem®
    同义词 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
    参考
    参考 Chen, L., et al. 2006. Mol. Pharmacol. 70, 562.
    产品信息
    CAS号 56932-43-5
    具有ATP竞争性 N
    形式 Redish brown solid
    Hill配方 C₁₉H₁₁N₃Na₂O₇S₂
    化学配方 C₁₉H₁₁N₃Na₂O₇S₂
    Molar Mass 503.4
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 SHP1/2 PTPase
    主靶IC50 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565851,SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,AB5604-200UL,Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1,L-type


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