merck millipore,默克密理愽
  • merck millipore,默克密理博,420116,JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

  • merck millipore,默克密理博,420116,JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

    产品名称：JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem
    产品型号：420116
    The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,420116,JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420116,JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

    重要规格表

    经验配方
    C₁₆₈H₂₉₃N₆₇O₄₂
    描述
    概述 A cell-permeable, biologically active peptide consisting of a carboxyl terminal sequence derived from the JNK-binding domain (JBD) and an amino terminal peptide containing the HIV-TAT48-57 sequence. Blocks c-Jun NH2-terminal kinase (JNK) signaling by preventing the activation of the transcription factor c-jun (IC50 ~ 1 µM). This effect appears to be due to inhibition of phosphorylation of the activation domains of JNK. Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB) that is shown to be critical for interaction with JNK linked to the 10-amino acid HIV-TAT48-57 sequence as a carrier peptide and two proline residues as spacer. Inhibits IL-1β-induced c-jun and c-fos expression in insulin secreting βTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no effect on either ERK 1/2 or p38 activities.
    产品目录编号 420116
    品牌系列 Calbiochem®
    同义词 (L)-JNKI1, (L)-HIV-TAT₄₈₋₅₇-PP-JBD₂₀, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂, c-Jun NH₂-terminal kinase, SAPK Inhibitor I
    参考
    参考 Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
    Bonny, C., et al. 2001. Diabetes 50, 77.
    产品信息
    具有ATP竞争性 N
    声明 Sold under license of U.S. Patents 6,043,083 and 6,410,693.
    形式 White lyophilized solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₆₈H₂₉₃N₆₇O₄₂
    化学配方 C₁₆₈H₂₉₃N₆₇O₄₂
    Molar Mass 3923.6
    吸湿 Hygroscopic
    肽序列 H-Gly-Arg-Lys-Lys-Arg-Agr-Gln-Arg-Arg-Arg-Pro-Pro-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-Pro-Gln-Val-Pro-Arg-Ser-Gln-Asp-Thr-NH₂
    可逆 N
    生物信息
    主靶 JNK
    主靶IC50 1 µM
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    肽序列 H-Gly-Arg-Lys-Lys-Arg-Agr-Gln-Arg-Arg-Arg-Pro-Pro-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-Pro-Gln-Val-Pro-Arg-Ser-Gln-Asp-Thr-NH₂
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420116,JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

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