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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT61 描述 Anti-INF2 Antibody Alternate Names - HBEBP2-binding protein C
- Inverted formin-2
背景信息 INF2 (inverted formin 2) is a mouse formin that has been found to interact with actin through the C-terminus to the formin homology 2 domain. The WASP homology 2 motif activates another region that appropriates actin monomers. INF2 has a unique ability to speed up polymerization and depolymerization of actin filaments. Mutations in the N-terminal diaphanous inhibitory domain of INF2 have been proven to be a main cause of familial focal segmental glomerulosclerosis. 产品信息 格式 Affinity Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl and 0.05% sodium azide. 应用 应用 Anti-INF2 Antibody is an antibody against INF2 for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot of this antibody detected INF2 in stomach cancer tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human INF2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHuman Species Reactivity Note Demonstrated to react with Human and Rat.
Other homologies: Mouse (68% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_071934
Entrez基因汇总 Summary: This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5. 基因符号 - C14orf173
- INF2
- C14orf151
纯化方法 Affinity Purified UniProt编号 - Q27J81
UniProt汇总 FUNCTION: Severs actin filaments and accelerates their polymerization and depolymerization (by similarity).
ENZYME REGULATION: Phosphate inhibits both the depolymerization and severing activities.
SUBUNIT STRUCTURE: Interacts with actin at the FH2 domain (by similarity).
SUBCELLULAR LOCATION: Cytoplasm › perinuclear region.
TISSUE SPECIFICITY: Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
DOMAIN: The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers (by similarity). Regulated by autoinhibition due to intramolecular GBD-DAD binding (by similarity). The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (by similarity).
INVOLVEMENT IN DISEASE: Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5) [MIM:613237]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
SEQUENCE SIMILARITIES: Belongs to the formin homology family. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Contains 1 WH2 domain.
SEQUENCE CAUTION: The sequence AAH08756.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH64828.1 differs from that shown. Reason: Erroneous initiation. The sequence ABD59343.1 differs from that shown. Reason: Erroneous initiation. The sequence ABD59344.1 differs from that shown. Reason: Erroneous initiation. The sequence ABD59345.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15224.1 differs from that shown. Reason: Erroneous termination at positions 636 and 759. Translated as Lys, Gln. The sequence EAW81872.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.05 µg/mL of this antibody detected INF2 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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