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经验配方 C₂₁H₁₆FN₃OS 描述 产品目录编号 559398 品牌系列 Calbiochem®
同义词 InSolution™ p38 MAP Kinase Inhibitor XVI 参考 参考 Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
Lee, J.C., et al. 1994. Nature 372, 739.产品信息 具有ATP竞争性 Y 形式 Liquid 配方 A 1 mg/ml solution of SB 203580 (Cat. No. 559389) in anhydrous DMSO. Hill配方 C₂₁H₁₆FN₃OS 化学配方 C₂₁H₁₆FN₃OS Molar Mass 377.4 可逆 Y 结构配方图像 生物信息 主靶 P38MAPK 主靶IC50 34 nM in vitro, 600 nM in cells against p38 MAPK; 50-100 nM Inhibiting IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM inhibiting platelet aggregation by collagen 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 24/25-26
Avoid contact with skin and eyes.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.储存和货运信息 货运代码 Blue Ice Only
毒性 Irritant
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C). 包装信息 惰性气体下包装 Packaged under inert gas
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