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merck millipore,默克密理博,AB9634,Anti-Post Synaptic Density 95 Antibody
产品名称：Anti-Post Synaptic Density 95 Antibody
产品型号：AB9634
This Anti-Post Synaptic Density 95 Antibody is validated for use in WB for the detection of Post Synaptic Density 95.
merck millipore,默克密理博,AB9634,Anti-Post Synaptic Density 95 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9634 Replaces 04-1066 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Post Synaptic Density 95 Antibody Alternate Names - PSD-95
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. 应用 应用 This Anti-Post Synaptic Density 95 Antibody is validated for use in WB for the detection of Post Synaptic Density 95. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from the N-terminal of rat PSD-95. 宿主 Rabbit 特异性 Postsynaptic density 95 (PSD-95). The antibody recognizes a protein of ~95 kDa corresponding to PSD-95 in lysates from rat brain hippocampus. An additional band of ~44 kDa may also be seen depending on sample and antibody concentration used. 同种型 IgG 品种反应性 Rat Species Reactivity Note The immunogen has 100% similarity with human and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001365.2
Entrez基因汇总 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. 基因符号 - PSD95
- DLG4
- SAP90
- PSD-95
UniProt编号 - P78352
UniProt汇总 FUNCTION: SwissProt: P78352 # Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
SIZE: 724 amino acids; 80495 Da
SUBUNIT: Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, and BEGAIN (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
TISSUE SPECIFICITY: Brain.
DOMAIN: SwissProt: P78352 The PDZ domain 3 mediates interaction with ADR1B. & The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.
PTM: Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity).
SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 3 PDZ (DHR) domains. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. 包装信息 数量 100 µL
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