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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS595 描述 Anti-TPI1 Antibody Alternate Names - TPI1
- Triosephosphate isomerase
- TIM
- Triose-phosphate isomerase
背景信息 Triosephosphate isomerase (TIM) or Triose-phosphate isomerase and encoded by the gene named TPI1/TPI is an isomerase that is important in glycolysis. It converts Dihydroxiacetone phosphate (glycerone phosphate) to D-glyeraldehyde 3-phosphate which then can be worked on by glyceraldehyde phosphate dehydrogenase to 1,3-bisphosphoglycerate and in the process make an NADH2. TPI1 conversion captures all of the isoforms arriving from the third step in glycolysis ensuring an efficient utilization of the available hexoses. Expressed by all cells and localized to the cytoplasm deficiencies are associated with anemias and severe neurological disorders including Alzheimer’s disease. Recent research using animal models that mimic early cognitive impairments seen in Alzheimer’s disease suggested that lowered TPI1 activity as the animals aged effected their ability to learn and remember, and interestingly, acupuncture treatments helped to restore TPI1 activity and recover from losses in memory. EMD-Millipore’s Anti-TPI1 rabbit polyclonal antibody has been tested in western blot on HepG2 cell lysates and in immunoprecipitation on HEK293 cell lysates. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol. 应用 应用 Detect Triosephosphate isomerase using this rabbit polyclonal antibody, Anti-TPI1 Antibody validated for use in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged fusion protein corresponding to human TPI1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - TPI
- TPI1
纯化方法 Antigen Affinity purified UniProt编号 - P60174
产品使用声明 质量保证 Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected TPI1 in HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.包装信息 数量 150 µL
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