merck millipore,默克密理博,04-1056,Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal

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merck millipore,默克密理博,04-1056,Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal
产品名称：Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal
产品型号：04-1056
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IDO Antibody, clone EPR1230Y, Rabbit is va More>>

merck millipore,默克密理博,04-1056,Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1056,Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	04-1056
描述	Anti-IDO Antibody, clone EPR1230Y, rabbit monoclonal
Alternate Names	IDO1 Indoleamine-pyrrole 2,3-dioxygenase indole 2,3-dioxygenase indoleamine 2,3-dioxygenase 1 indoleamine-pyrrole 2,3 dioxygenase
背景信息	Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

产品信息
格式	Diluted Culture Supernatant
控制	HeLa + IFN-γ cell lysate
演示	Rabbit Monoclonal IgG in buffer containing 50mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IDO Antibody, clone EPR1230Y, Rabbit is validated for use in WB for the detection of IDO.
主要应用	Western Blotting

生物信息
免疫原品种	Synthetic peptide corresponding to residues within human IDO.
克隆	EPR1230Y
宿主	Rabbit
特异性	This antibody recognizes IDO.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002155.1
Entrez基因汇总	Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM]
基因符号	INDO IDO
UniProt编号	P14902
UniProt汇总	FUNCTION: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. CATALYTIC ACTIVITY: D-tryptophan + O2 = N-formyl-D-kynurenine. L-tryptophan + O2 = N-formyl-L-kynurenine. COFACTOR: Binds 1 heme group per subunit. INDUCTION: By interferon gamma. SEQUENCE SIMILARITIES: Belongs to the indoleamine 2,3-dioxygenase family

产品使用声明
质量保证	Evaluated by Western Blotting on HeLa + IFN-γ cell lysates. Western Blotting Analysis: 1:2,500-5,000 dilution of this antibody detected IDO in HeLa + IFN-γ cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.