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merck millipore,默克密理博,MABS18,Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1
产品名称：Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1
产品型号：MABS18
Detect Aldose reductase using this Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1 validated for use in WB.
merck millipore,默克密理博,MABS18,Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS18 描述 Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1 Alternate Names - Aldehyde reductase
- aldo-keto reductase family 1, member B1 (aldose reductase)
- aldose reductase
- Aldo-keto reductase family 1 member B1
- low Km aldose reductase
- Lii5-2 CTCL tumor antigen
- aldehyde reductase 1
背景信息 Aldose reductase (AR) is s a therapeutic target for treatment of long-term obstacles of diabetes. AR has also been shown to be a component of antioxidant defense and of stress-induced signaling. It is an important component of cellular redox state and regulation of signaling cascades that may play a part in regulating cytotoxic occurrences. 产品信息 格式 Purified 控制 - Human kidney tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Aldose reductase using this Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1 validated for use in WB. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.) 生物信息 免疫原品种 Full length recombinant protein corresponding to human Aldose reductase.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.克隆 CPTC-AKR1B1-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001619
Entrez基因汇总 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq]. 基因符号 - ALR2
- AR
- ALDR1
- ADR
纯化方法 Protein G UniProt编号 - P15121
UniProt汇总 FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
CATALYTIC ACTIVITY: Alditol + NAD(P)+ = aldose + NAD(P)H.
ENZYME REGULATION: Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.
SUBUNIT STRUCTURE: Monomer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
SEQUENCE SIMILARITIES: Belongs to the aldo/keto reductase family.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.001 µg/mL of this antibody detected Aldose reductase on 10 µg of human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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