merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC44,Anti-LAMP-3 Antibody, clone 16H11.2

  • merck millipore,默克密理博,MABC44,Anti-LAMP-3 Antibody, clone 16H11.2

    产品名称：Anti-LAMP-3 Antibody, clone 16H11.2
    产品型号：MABC44
    Detect LAMP-3 using this Anti-LAMP-3 Antibody, clone 16H11.2 validated for use in WB, IH.

    merck millipore,默克密理博,MABC44,Anti-LAMP-3 Antibody, clone 16H11.2

  • 产品介绍
  • merck millipore,默克密理博,MABC44,Anti-LAMP-3 Antibody, clone 16H11.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC44
    描述 Anti-LAMP-3 Antibody, clone 16H11.2
    Alternate Names
    • Protein TSC403
    • LAMP
    • CD208
    • LAMP-3
    • DC-loysosome-associated membrane glycoprotein
    • DC LAMP
    • DC-LAMP
    背景信息 Lysosyme-associated membrane proteins (LAMP) are transmembrane lysosomal glycoproteins, which share a common Gly-Tyr motif as a lysosomal targeting signal. While LAMP-1 and LAMP-2 contain type 1 transmembrane domains, LAMP-3 contains a transmembrane 4 superfamily domain, tetraspanin. FceRI-mediated stimulation of basophils causes LAMP-3 to be translocated from its intracellular localization to the plasma membrane. LAMP-3 thereby serves as a reliable marker for basophil activation. LAMP-3 expression is known to be reported in human bone marrow mast cells and in leukemic human mast cell line (HMC-1), among other cell lines. LAMP3 is shown to be regulated by hypoxia in a panel of tumor cells, via the unfolded protein response (UPR). UPR is a mechanism of adaptation to endoplasmic reticulum stress and is demonstrated to contribute to hypoxic adaptation in tumors through multiple mechanisms.
    产品信息
    格式 Purified
    控制
    • MCF-7 cell lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect LAMP-3 using this Anti-LAMP-3 Antibody, clone 16H11.2 validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected LAMP-3 in colorectal adenocarcinoma tissue.
    生物信息
    免疫原品种 Recombinant protein corresponding to human LAMP-3.
    克隆 16H11.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_055213
    Entrez基因汇总 Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998).
    基因符号
    • TSC403
    • LAMP3
    • DCLAMP
    纯化方法 Protein G purified
    UniProt编号
    • Q9UQV4
    UniProt汇总 FUNCTION: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells.

    SUBCELLULAR LOCALIZATION: Lysosome membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICITY: Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
    产品使用声明
    质量保证 Evaluated by Western Blot in MCF-7 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-3 in MCF-7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC44,Anti-LAMP-3 Antibody, clone 16H11.2

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