merck millipore,默克密理博,ABS468,Anti-APOL1 Antibody

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merck millipore,默克密理博,ABS468,Anti-APOL1 Antibody
产品名称：Anti-APOL1 Antibody
产品型号：ABS468
Detect Apolipoprotein using this rabbit polyclonal antibody, Anti-APOL1 Antibody validated for use in western blotting, IHC & Immunofluorescence.

merck millipore,默克密理博,ABS468,Anti-APOL1 Antibody

产品介绍

merck millipore,默克密理博,ABS468,Anti-APOL1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABS468
描述	Anti-APOL1 Antibody
Alternate Names	APOL1 Apolipoprotein L1 Apolipoprotein L Apo-L ApoL Apolipoprotein L-I ApoL-I
背景信息	Apolipoprotein L1/Apolipoprotein L-1 (ApoL-1, APOL1), or alternatively Apolipoprotein L (Apo-L/ApoL) is the protein encoded by the APOL1 gene in humans. APOL1 is one of the major carriers of cholesterol in the blood. It plays a role in the transport of cholesterol from the peripheral cells to the liver. It is a secreted protein expressed in liver, pancreas, lung, prostate, placenta and spleen. APOL1 is part of the HDL (high density lipoprotein) complex and APOL1 possesses both extra- and intra-cellular functions crucial in host defense and cellular homeostatic mechanisms. Alterations in APOL1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD), yet much of its biological function remains unknown. Interesting, APOL1 has the ability to kill circulating trypanosomes in the blood. Trypanosomes cause a serious disease called sleeping sickness but in those individuals that have particular splice variants of APOL1 are spared sleeping sickness, however the variants are associated with an increased chance of kidney disease as a tradeoff. APOL1 appears important in autophagy and even as a cancer preventative as well. Recent research shows that increased intracellular levels of APOL1 can induce autophagy and autophagy-associated cell death but that Apolipoprotein L1 may protect kidney cells against renal cell carcinoma. EMD-Millipore’s Anti-APOL1 rabbit ployclonal antibody has been tested in western blot using human blood, in paraffin embedded immunohistochemistry on human kidney tissue sections, and in immunofluorescence in HepG2 cells.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Detect Apolipoprotein using this rabbit polyclonal antibody, Anti-APOL1 Antibody validated for use in western blotting, IHC & Immunofluorescence.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected APOL1 in human kidney tissue. Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected APOL1 in HepG2 cells.

生物信息
免疫原品种	GST-tagged fusion protein corresponding to human APOL1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	APOL APOL1
纯化方法	Antigen Affinity purified
UniProt编号	O14791

产品使用声明
质量保证	Evaluated by Western Blotting in human blood tissue. Western Blotting Analysis: A 1:800 dilution of this antibody detected APOL1 in human blood tissue.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.