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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN469 描述 Anti-DISC1 Antibody Alternate Names - KIAA0457
- DISC1 Antibody
- Disrupted in schizophrenia 1 protein
背景信息 Disrupted in schizophrenia 1 protein (DISC1) is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 may play a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. DISC1 is shown to inhibit the activation of AKT-mTOR signaling upon interaction with CCDC88A. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Additionally, DISC1 is suggested to regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. DISC1 has been shown to participates in the Wnt-mediated neural progenitor proliferation as a positive regulator and may have a role, together with PCNT, in the microtubule network formation.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.
产品信息 格式 Affinity Purified 控制 - NIH/3T3 cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-DISC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Disc1 & has been tested in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the N-terminus of human DISC1. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the N-terminus of DISC1. 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human based on 100% sequence homology. 抗体类型 Polyclonal Antibody 基因符号 - DISC1
纯化方法 Antigen Affinity purified UniProt编号 - Q9NRI5
产品使用声明 质量保证 Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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