merck millipore,默克密理愽
  • merck millipore,默克密理博,ABS233,Anti-PI3 Kinase p85 Antibody, N-SH2 domain

  • merck millipore,默克密理博,ABS233,Anti-PI3 Kinase p85 Antibody, N-SH2 domain

    产品名称：Anti-PI3 Kinase p85 Antibody, N-SH2 domain
    产品型号：ABS233
    Detect PI3 Kinase, p85 using this rabbit polyclonal antibody, Anti-PI3 Kinase p85 Antibody, N-SH2 domain validated for use in western blotting & IP.

    merck millipore,默克密理博,ABS233,Anti-PI3 Kinase p85 Antibody, N-SH2 domain

  • 产品介绍
  • merck millipore,默克密理博,ABS233,Anti-PI3 Kinase p85 Antibody, N-SH2 domain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABS233
    Replaces 06-496
    描述 Anti-PI3 Kinase p85 Antibody, N-SH2 domain
    Alternate Names
    • PtdIns-3-kinase regulatory subunit p85-alpha
    • Phosphatidylinositol 3-kinase regulatory subunit alpha
    • PI3-kinase regulatory subunit alpha
    • PI3K regulatory subunit alpha
    • PtdIns-3-kinase regulatory subunit alpha
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
    • PI3-kinase subunit p85-alpha
    背景信息 Phosphatidylinositol 3-Kinase (PI3 Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibited by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
    产品信息
    格式 Affinity Purified
    控制
    • Jurkat cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect PI3 Kinase, p85 using this rabbit polyclonal antibody, Anti-PI3 Kinase p85 Antibody, N-SH2 domain validated for use in western blotting & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot immunoprecipitated PI3 Kinase p85, N-SH2 domain in 0.5mg of Jurkat cell lysate.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to the N-SH2 domain of rat PI3 Kinase p85.
    表位 N-SH2 domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the N-SH2 domain of PI3 Kinase p85
    品种反应性 RatHuman
    Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Mouse, Bovine, and Monkey based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037137
    基因符号
    • Pik3r1
    纯化方法 Affinity purified
    UniProt编号
    • Q63787
    产品使用声明
    质量保证 Evaluated by Western Blotting in Jurkat cell lysate.

    Western Blotting Analysis: 0.25 µg/mL of this antibody detected PI3 Kinase p85, N-SH2 in 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABS233,Anti-PI3 Kinase p85 Antibody, N-SH2 domain

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