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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 07-577 品牌系列 Upstate
商名 - Upstate
描述 Anti-Stargazin/Cacng2 Antibody, CT Alternate Names - voltage-dependent calcium channel gamma-2 subunit
- Neuronal voltage-gated calcium channel gamma-2 subunit
- calcium channel, voltage-dependent, gamma subunit 2
- voltage-dependent
- gamma subunit 2
背景信息 Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state.
There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.产品信息 格式 Purified 控制 - Brain tissue
演示 Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. 应用 应用 This Anti-Stargazin/Cacng2 Antibody, CT is validated for use in IC, IP, WB for the detection of Stargazin/Cacng2. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Immunoprecipitation:
2-5 µg of this antibody has been reported by an independent laboratory to immunoprecipitate Stargazin in rat P2 lysate.生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 305-323 (KDSKDSLHANTANRRTTPV) of rat Stargazin. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Stargazin, MW ~36-39 kDa. 同种型 IgG 品种反应性 MouseRat Species Reactivity Note Rat. Predicted to cross-react with mouse based on sequence similarity. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006069
Entrez基因汇总 L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. 基因符号 - stargazin
- CACNG2
- MGC138502
- MGC138504
纯化方法 Protein A purfied UniProt编号 - Q9Y698
UniProt汇总 FUNCTION: SwissProt: Q9Y698 # Thought to stabilize the calcium channel in an inactivated (closed) state.
SIZE: 323 amino acids; 35966 Da
SUBUNIT: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain.
PTM: Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.
SIMILARITY: SwissProt: Q9Y698 ## Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.产品使用声明 质量保证 Evaluated by western blot on RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).
Western Blot Analysis:
0.5-2.0 µg/mL of this antibody detected Stargazin in RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µg
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