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品种反应性 主要应用 宿主 格式 抗体类型 R, Ch, H, Ht, M WB, ELISA, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1936 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α2 Antibody Alternate Names - CD49b
产品信息 格式 Serum 控制 - Skin (basement membrane), High grade ovarian tumors
演示 Neat rabbit antiSerum. Liquid with 0.05% sodium azide 应用 应用 Anti-Integrin α2 Antibody detects level of Integrin α2 & has been published & validated for use in ELISA, IF, IH, IP, RIA & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Immunofluorescence: 1:500 (suggested for use on acetone-fixed tissue only)
ELISA/RIA: 1:1000
Western blot: 1:1000 The antibody has been used to report alpha2 expression in HUVECs during tubule-like structure formation in collagen (Deroanne, 1996). Recognizes ~160kDa alpha 2 subunit
Immunoprecipitation: 5 μL precipitates alpha2/beta1 from 5 x 106 cells.
Immunohistochemistry: 1:500
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human alpha2 integrin subunit {KYEKMTKNPDEODETTELSS} 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Human alpha2 integrin subunit. Specificity determined by immunoprecipitation from a detergent extract of 35S methionine labeled endothelial cells. The epitope recognized is on the cytoplasmic domain of the protein and is thus intracellular. Shows no cross-reactivity to alpha1, alpha3, alpha4, alpha5, alpha6, or alphaV subunits. 品种反应性 RatChickenHumanHamsterMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002203.3
Entrez基因汇总 This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. 基因符号 - GPIa
- ITGA2
- CD49B
- VLAA2
- VLA-2
- CD49b
- BR
纯化方法 Unpurified UniProt编号 - P17301
UniProt汇总 FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
SIZE: 1181 amino acids; 129295 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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