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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS179 描述 Anti-ADAP1 Antibody Alternate Names - Putative MAPK-activating protein PM25
- Arf-GAP with dual PH domain-containing protein 1
- Centaurin-alpha-1
- Cnt-a1
背景信息 Arf-GAP with dual PH domain-containing protein 1 (ADAP1), also known as p42(IP4), PIP3BP, or centaurin-alpha1, is a highly abundant brain protein that has been detected in the hippocampus, cerebellum, cortex, and hypothalamus. It is an actin-binding protein that has been localized to the nucleus, cytoplasm, plasma membrane, and mitochondria. ADAP1 contains a zinc finger motif and two pleckstrin homology domains. It functions as a receptor for inositol(1,3,4,5)tetrakisphosphate and phosphatidylinositol(3,4,5)trisphosphate second messengers, and also binds to and becomes phosphorylated by all isoforms of PKC. It has been linked to calcium transport in the mitochondria and RNA metabolism in the nucleus. In addition, it has been shown that ADAP1 modulates the development and differentiation of dendrites in hippocampal cells, as it is involved in the formation of dendritic filopodia and spine-like protrusions. It has also been reported that ADAP1 is upregulated in Alzheimer’s disease. 产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-ADAP1 Antibody is validated for use in Western Blotting, IHC(P) for the detection of ADAP1. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A representative lot detected ADAP1 in normal mouse cerebellum and hippocampus tissues.
Western Blot Analysis: A representative lot detected ADAP1 in human brain tissue lysate.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP1. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of ADAP1. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006860
基因符号 - CENTA1
- ADAP1
纯化方法 Affinity purified UniProt编号 - O75689
产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1 mg/mL of this antibody detected ADAP1 in 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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