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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC241 描述 Anti-IRE1 Antibody Alternate Names - Endoribonuclease
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Endoplasmic reticulum-to-nucleus signaling 1
- Inositol-requiring protein 1
- hIRE1p
- Ire1-alpha
- IRE1a
- Serine/threonine-protein kinase
背景信息 Inositol-requiring protein 1 (IRE1p), also known as Ire1-alpha (IRE1a), Endoplasmic reticulum-to-nucleus signaling 1 (ERN1), and Serine/threonine-protein kinase/endoribonuclease IRE1, contains 1 KEN domain and 1 protein kinase domain.
IRE1p has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. IRE1p is ubiquitously expressed with high levels observed in pancreatic tissue.产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Inositol-requiring protein 1 using this rabbit polyclonal antibody, Anti-IRE1 Antibody validated for use in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the Lumenal domain of human IRE1. 表位 Lumenal domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Predicted to react with Mouse, Rat, Porcine, and Primate based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001424.3
基因符号 - IRE1
- ERN1
纯化方法 Affinity purified UniProt编号 - O75460
产品使用声明 质量保证 Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected IRE1 in 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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