merck millipore,默克密理愽
  • merck millipore,默克密理博,616453,TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

  • merck millipore,默克密理博,616453,TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem
    产品型号：616453
    The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dep More>>

    merck millipore,默克密理博,616453,TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616453,TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₁N₃O₂ • HCl356559-13-2
    描述
    概述 A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
    产品目录编号 616453
    品牌系列 Calbiochem®
    同义词 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, ALK5 Inhibitor III, SB-505124, HCl
    参考
    参考 Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
    DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
    产品信息
    CAS号 356559-13-2
    具有ATP竞争性 Y
    形式 Light yellow solid
    Hill配方 C₂₀H₂₁N₃O₂ • HCl
    化学配方 C₂₀H₂₁N₃O₂ • HCl
    Molar Mass 371.9
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 Activin receptor-like kinase 4, 5, 7
    主靶IC50 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616453,TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

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