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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN96 描述 Anti-Neurexin3 Antibody Alternate Names - Neurexin III-alpha
- Neurexin-3-alpha
背景信息 Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion. (Missler, M., et al. (1998) 14(1):20-26) Antibody Anti-neurexin 3 alpha (ABN96) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human neurexin 3 alpha (Uniprot Q9Y4C0). Although the theoretical full length of Neurexin 1alpha is 180 kDa, the protein detected in human brain lysates may show a band around 180 kDa and additional bands around 40-55 kDa as a possible result of the posttranslational processing previously reported. 产品信息 格式 Affinity Purified 控制 - PC12 cell lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Neurexin3 using this Anti-Neurexin3 Antibody validated for use in WB, IH. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Neurexin-3 in normal mouse brain tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Neurexin-3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004787
Entrez基因汇总 Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. 基因符号 - KIAA0743
- NRXN3
- C14orf60
纯化方法 Affinity purified UniProt编号 - Q9Y4C0
UniProt汇总 FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
SUBUNIT STRUCTURE: The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.产品使用声明 质量保证 Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Neurexin-3 in 10 µg of PC12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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