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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN408 描述 Anti-MPRIP Antibody Alternate Names - p116Rip
- Myosin phosphatase Rho-interacting protein
- M-RIP
- Rho-interacting protein 3
- RIP3
背景信息 MPRIP, also known as Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, or p116Rip, and encoded by the gene MPRIP/KIAA0864/MRIP/RHOIP3, is an important regulator or actin cytoskeleton interactions. In muscle and neurons MPRIP targets myosin phosphatase to the actin cytoskeleton and its interaction with phosphorylated myosin. Overexpression of MPRIP leads to disassembly of actin stress fibers in neuronal and other cells types. MPRIP though its interaction with the actin cytoskeleton modulates cell morphology, particularly in neurons and strongly structural cell types, and MPRIP appears to play a key role in the JNK signaling cascade and in cell motility in invasive cancer cells, thus MPRIP is a current target for anti-cancer therapy. MPRIP interacts with RHOA, ROCK, MYZAP, Syntenin-1 and other cell structure associated proteins. MPRIP co-localizes with F-actin in most cells, and thus it is largely cytoplasmically localized. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MPRIP Antibody detects level of MPRIP & has been published & validated for use in MPRIP. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected MPRIP in human stomach and human cerebellum tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human MPRIP. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHuman Species Reactivity Note Human, Rat. Predicted to react with Chimpanzee, Canine, Feline, Ferret, Gorilla, Giant Panda based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055949
基因符号 - RHOIP3
- MPRIP
- KIAA0864
- MRIP
纯化方法 Affinity purified UniProt编号 - Q6WCQ1
产品使用声明 质量保证 Evaluated by Western Blotting in SH-SY5Y cell lysate.
Western Blotting Analysis: 3.0 µg/mL of this antibody detected MPRIP in 10 µg of SH-SY5Y cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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