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merck millipore,默克密理博,AB4326,Anti-ISL-1 Antibody
产品名称：Anti-ISL-1 Antibody
产品型号：AB4326
Anti-ISL-1 Antibody is a Rabbit Polyclonal Antibody for detection of ISL-1 also known as ISL LIM homeobox 1, ISL1 transcription factor LIM/homeodomain & has been validated in WB & IHC.
merck millipore,默克密理博,AB4326,Anti-ISL-1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Ca, H, M, Eq, B, Sh, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB4326 描述 Anti-ISL-1 Antibody Alternate Names - ISL1 transcription factor, LIM/homeodomain, (islet-1)
- ISL LIM homeobox 1
- ISL1 transcription factor, LIM/homeodomain
背景信息 Islet-1 (ISL-1) is a transcription factor that plays an important role in the embryogenesis of pancreatic islets of Langerhans. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. In mouse embryos, a deficiency of this gene fail to undergo neural tube motor neuron differentiation. More recently it has been identified as a marker for a cardiac progenitor cell lineage that is capable of differentiating into all 3 major heart cell types: cardiomyocytes, smooth muscle and endothelial cell lineages. 产品信息 格式 Affinity Purified 控制 - K562 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-ISL-1 Antibody is a Rabbit Polyclonal Antibody for detection of ISL-1 also known as ISL LIM homeobox 1, ISL1 transcription factor LIM/homeodomain & has been validated in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected ISL-1 in mouse pancreas tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ISL-1. 表位 Internal region of ISL-1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes ISL-1. 品种反应性 CanineHumanMouseHorseBovineSheepRat Species Reactivity Note Tested to react with human and mouse.
Predicted to react with equine, bovine, sheep, rat, canine, and most common vertebrate species based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002193
Entrez基因汇总 This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq]. 基因符号 - ISL-1
- ISL1
- islet-1
- Islet-1
- Isl-1
纯化方法 Affinity Purfied UniProt编号 - P61371
UniProt汇总 FUNCTION: SwissProt: P61371 # Binds to one of the cis-acting domain of the insulin gene enhancer.
SIZE: 349 amino acids; 39036 Da
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
SIMILARITY: SwissProt: P61371 ## Contains 1 homeobox DNA-binding domain. & Contains 2 LIM zinc-binding domains.产品使用声明 质量保证 Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected ISL-1 on 10 µg of K562 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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