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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN241 Replaces PC246-100UG 描述 Anti-GluR1 Antibody Alternate Names - GluA1
- Glutamate receptor 1
- GluR-1
- AMPA-selective glutamate receptor 1
- GluR-A
- GluR-K1
- Glutamate receptor ionotropic, AMPA 1
背景信息 Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. 产品信息 格式 Affinity Purified 控制 - Rat brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1. 表位 Extracellular domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the extracellular domain of GluR1. 品种反应性 HumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_113796
基因符号 - Glur1
- Gria1
纯化方法 Affinity purified UniProt编号 - P19490
产品使用声明 质量保证 Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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