merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10553,Anti-Prohormone Convertase PC1/PC3 Antibody

  • merck millipore,默克密理博,AB10553,Anti-Prohormone Convertase PC1/PC3 Antibody

    产品名称：Anti-Prohormone Convertase PC1/PC3 Antibody
    产品型号：AB10553
    Anti-Prohormone Convertase PC1/PC3 Antibody is an antibody against Prohormone Convertase PC1/PC3 for use in WB, IC, IH.

    merck millipore,默克密理博,AB10553,Anti-Prohormone Convertase PC1/PC3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10553,Anti-Prohormone Convertase PC1/PC3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHC, WB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB10553
    描述 Anti-Prohormone Convertase PC1/PC3 Antibody
    Alternate Names
    • proprotein convertase subtilisin/kexin type 1
    • NEC 1
    • Prohormone convertase 1
    • Proprotein convertase 1
    • neuroendocrine convertase 1
    • prohormone convertase 3
    背景信息 The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
    产品信息
    格式 Affinity Purified
    控制
    • Mouse adrenal gland tissue lysate
    演示 Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Prohormone Convertase PC1/PC3 Antibody is an antibody against Prohormone Convertase PC1/PC3 for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: 1: 500 dilution from a previous lot detected Prohormone Convertase PC1/PC3 in HeLa, C2C12, NIH/3T3 cell lysates.
    生物信息
    免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated linear peptide within human Prohormone Convertase PC1/PC3.
    表位 Mature Chain
    宿主 Rabbit
    特异性 This antibody recognizes Prohormone Convertase PC1/PC3.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse and rat. Predicted to react with pig based on sequence homology. Ape, dog, and rat (97%). Bovine (95%).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000439.3
    基因符号
    • SPC3
    • BMIQ12
    • EC 3.4.21.93
    • NEC1
    • PC1
    • PC3
    纯化方法 Affinity Purfied
    UniProt编号
    • P29120
    UniProt汇总 FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
    CATALYTIC ACTIVITY: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
    COFACTOR: Calcium.
    SUBCELLULAR LOCATION: Cytoplasmic vesicle › secretory vesicle. Note: Localized in the secretion granules.
    POLYMORPHISM: Genetic variations in PCSK1 define the body mass index quantitative trait locus 12 (BMIQ12) [MIM:612362]. Variance in body mass index is a susceptibility factor for obesity.
    INVOLVEMENT IN DISEASE: Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
    SEQUENCE SIMILARITIES: Belongs to the peptidase S8 family. Furin subfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse adrenal gland tissue lysate.
    Western Blot Analysis: : 0.5 µg/mL of this lot detected Prohormone Convertase PC1/PC3 on 10 µg of mouse adrenal gland tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB10553,Anti-Prohormone Convertase PC1/PC3 Antibody

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