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品种反应性 主要应用 宿主 格式 抗体类型 H, M, R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN194 描述 Anti-EVI-5 Antibody Alternate Names - EVI-5
- Ecotropic viral integration site 5 protein homolog
背景信息 Also known as Ecotropic viral integration site 5 protein homolog, EVI-5 serves as a key regulator of the cell cycle through time-dependent stabilization of Emi1, FBX05 protein, and APC/C ubiquitination substrates, such as cyclin A. EVI-5 accumulates in early G1 following Plk1 destruction, but is degraded in a Plk1- and ubiquitin-dependent manner in early mitosis. EVI-5 ablation causes premature APC/C activation, SCF(betaTrCP)-dependent Emi1 degradation, and cyclin destruction, all of which leads to cell cycle arrest and cytokinesis failure. It exists as a monomer and a dimer, and it may form complexes with alpha- and gamma-tubulin or interact with the INCENP-aurora B kinase-survivin chromosomal passenger complex. EVI-5 is implicated in abnormal states, such as multiple sclerosis and neuroblastoma. 产品信息 格式 Affinity Purified 控制 - Mouse and rat brain tissues
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This EVI-5 antibody is validated for use in IHC & WB for the detection of the EVI-5 protein. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis: 2 µg/mL from a representative lot detected EVI-5 in NIH/3T3 nuclear extract. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the human EVI-5. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HumanMouseRat Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Human based upon immunogen design. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005656
基因符号 - NB4S
- EVI5
纯化方法 Affinity purified UniProt编号 - O60447
产品使用声明 质量保证 Evaluated by Immunohistochemistry in mouse and rat brain tissues.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected EVI-5 in mouse and rat brain tissues.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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