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merck millipore,默克密理博,AB5535,Anti-Sox9 Antibody
产品名称：Anti-Sox9 Antibody
产品型号：AB5535
Anti-Sox9 Antibody is a well characterized affinity purified Rabbit Polyclonal Antibody that reliably detects Transcription Factor Sox-9. This highly published antibody has been validated in IHC & WB More>>
merck millipore,默克密理博,AB5535,Anti-Sox9 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5535 Replaces AB5809 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sox9 Antibody 背景信息 Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. 产品信息 格式 Affinity Purified 控制 - Embryonic tissue, Adult chondrocytes.
演示 Purified rabbit polyclonal in buffer containing 0.1M Tris -Glycine, 0.15M NaCl, 0.05% sodium azide, pH7.4. 应用 应用 Anti-Sox9 Antibody is a well characterized affinity purified Rabbit Polyclonal Antibody that reliably detects Transcription Factor Sox-9. This highly published antibody has been validated in IHC & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot:
1:500 dilution of a previous lot ~65kDa band
EMSA supershift
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from human Sox9. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Sox9. 品种反应性 RatHumanMouse Species Reactivity Note Human, rat and fetal mouse. Other species have not yet been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000337
Entrez基因汇总 The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. 基因符号 - SRA1
- SOX9
- CMPD1
- CMD1
纯化方法 Immunoaffinity purified UniProt编号 - P48436
UniProt汇总 FUNCTION: SwissProt: P48436 # Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
SIZE: 509 amino acids; 56137 Da
SUBCELLULAR LOCATION: Nucleus (Potential).
DISEASE: SwissProt: P48436 # Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male- to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.
SIMILARITY: SwissProt: P48436 ## Contains 1 HMG box DNA-binding domain产品使用声明 质量保证 Routinely evaluated by Western Blot on L6 cell lysates.
Western Blot Analysis: 1:2000 dilution of this lot detected SOX-9 on 10 μg of L6 cell lysate使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt. 包装信息 数量 100 µg
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