merck millipore,默克密理愽
  • merck millipore,默克密理博,400089,HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

  • merck millipore,默克密理博,400089,HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

    产品名称：HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem
    产品型号：400089
    The HIF-1α/2α Inhibitor IV, FM19G11, also referenced under CAS 329932-55-0, controls the biological activity of HIF-1α/2α. This small molecule/inhibitor is primarily used for Cell Structure applicatio More>>

    merck millipore,默克密理博,400089,HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,400089,HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₁₇N₃O₈329932-55-0
    描述
    概述 A cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 hours with 500 nM FM19G11.
    产品目录编号 400089
    品牌系列 Calbiochem®
    同义词 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV
    参考
    参考 Moreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.
    产品信息
    CAS号 329932-55-0
    形式 Pale amber solid
    Hill配方 C₂₃H₁₇N₃O₈
    化学配方 C₂₃H₁₇N₃O₈
    Molar Mass 463.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Use only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,400089,HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

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