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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN161 描述 Anti-pan Neurexin-1 Antibody Alternate Names - Neurexin I-alpha
- Neurexin-1-alpha
背景信息 Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Studies have shown mutations in the genese encoding for neurexins are impicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs acta as receptors for neuroligin and has been found to play a role in angiogenesis. Pan-neurexin antibodies recognize all neurexin isoforms. 产品信息 格式 Affinity Purified 控制 - Mouse brain membrane tissue lysate
演示 Purified rabbit polyclonal in preservative free buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl. 应用 应用 Anti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 & has been published & validated for use in WB, IH, IC & IP. 主要应用 - Immunocytochemistry
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected pan Neurexin-1-alpha in normal mouse cerebellum and normal rat cerebellum tissues.
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in E18 chicken embryo arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in E18 chicken brain arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.)生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human pan Neurexin-1-alpha. 表位 C terminus, 100% conserved between alpha and beta versions of Neurexin 1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Pan Neurexin 1 and there is a 75% overlap with Neurexin 2 and 3. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001129131
Entrez基因汇总 Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]. 基因符号 - NRXN1
纯化方法 Affinity purified UniProt编号 - Q9ULB1
UniProt汇总 FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
SUBUNIT STRUCTURE: The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Heart and brain.
PTM: N- and O-glycosylated (By similarity).
SEQUENCE SIMILARITIES: Belongs to the neurexin family.
Contains 3 EGF-like domains.
Contains 6 laminin G-like domains.
SEQUENCE CAUTION: The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by Western Blot in mouse brain membrane tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected pan Neurexin-1-alpha on 10 µg of mouse brain membrane tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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