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merck millipore,默克密理博,361571,InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem
产品名称：InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem
产品型号：361571
The InSolution™ GSK-3 Inhibitor XVI, CHIR99021, also referenced under CAS 252917-06-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & More>>
merck millipore,默克密理博,361571,InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,361571,InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem
重要规格表
经验配方 CAS号 C₂₂H₁₈Cl₂N₈ 252917-06-9 描述 概述 A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. The solid form of this compound (Cat. No. 361559) is also available. 产品目录编号 361571 品牌系列 Calbiochem®
同义词 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile 参考 参考 Mussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
Ring, D.B., et al. 2003. Diabetes 52, 588.
Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
Cline, G.W., et al. 2002.
Diabetes 51, 2903.产品信息 CAS号 252917-06-9 形式 Liquid 配方 A 25 mM (5 mg/430 µL) solution of GSK-3 Inhibitor XVI, CHIR99021 (Cat. No. 361559) in DMSO. Hill配方 C₂₂H₁₈Cl₂N₈ Molar Mass 465.3 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 GSK-3 α and β 主靶IC50 10 and 6.7 nM against GSK-3&alpha 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Dry Ice Only
毒性 Irritant
储存 ≤ -70°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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