- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,341291,Fas/FasL Antagonist, Kp7-6 - Calbiochem
产品名称：Fas/FasL Antagonist, Kp7-6 - Calbiochem
产品型号：341291
The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,341291,Fas/FasL Antagonist, Kp7-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₄₈H₅₆N₁₀O₁₅S₂ 描述 概述 An exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR. 产品目录编号 341291 品牌系列 Calbiochem®
同义词 H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6 参考 参考 Carmona, E.M., et al. 2006. J. Immunol. 177, 459.
Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.产品信息 具有ATP竞争性 N 声明 Sold under license of U.S. Patent 7,288,519. 形式 White lyophilized powder 配方 Supplied as a trifluoroacetate salt. Hill配方 C₄₈H₅₆N₁₀O₁₅S₂ 化学配方 C₄₈H₅₆N₁₀O₁₅S₂ Molar Mass 1077.2 吸湿 Hygroscopic
肽序列 H₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys] 可逆 N 生物信息 主靶 Fas/FasL-mediated cellular apoptotic signals 主靶IC50 Kd = 11.2 & 13.2 µM for FasL and Fas (CD95/APO-1), respectively 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 肽序列 H₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys] 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,12-645-K,mTOR Substrate
下一件merck millipore产品：merck millipore,默克密理博,ABN293,Anti-Prohibitin Antibody
相关产品
merck millipore,默克密理博,MABT391,Anti-Myosin-10 Antibody, clone 5H4.1
merck millipore,默克密理博,MAB13431,Anti-MMP-2 Antibody, pro and active form, clone A-Gel VC2
merck millipore,默克密理博,MAB1217FX-K,Anti-Fmc-7 B-Cell Lymphocyte Marker, clone Fmc-7, FITC conj (1mL)
merck millipore,默克密理博,ABN161,Anti-pan Neurexin-1 Antibody
merck millipore,默克密理博,12-645-K,mTOR Substrate
merck millipore,默克密理博,ABN293,Anti-Prohibitin Antibody
merck millipore,默克密理博,MAB5326B,Anti-Nestin Antibody, clone 10C2, Biotin Conjugate
merck millipore,默克密理博,MABE230,Anti-SMN2 Antibody, clone SMN-KH
merck millipore,默克密理博,SCM107,Human OPC Expansion Culture Media Kit