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描述 产品目录编号 12-645-K 品牌系列 Upstate
商名 - Upstate
描述 mTOR Substrate 概述 N-terminal 6His-tagged recombinant human mTOR substrate, expressed in E.coli. 产品信息 演示 mTOR substrate in 50mM Tris-HCl pH 7.5, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. 生物信息 Entrez基因编号 - NM_004958.2
Entrez基因汇总 The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene. 基因符号 - RAFT1
- FRAP1
- FRAP
- RAPT1
- FLJ44809
- FRAP2
- MTOR
- mTOR
蛋白靶 mTOR (FRAP1) 靶子系列 Lipid/Atypical UniProt编号 - P42345
UniProt汇总 FUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
SIZE: 2549 amino acids; 288892 Da
SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.
TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -80°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. 包装信息 数量 1 mg
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