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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF198 描述 Anti-NALP3 Antibody Alternate Names - PYRIN-containing APAF1-like protein 1
- NACHT, LRR and PYD domains-containing protein 3
- Angiotensin/vasopressin receptor AII/AVP-like
- Caterpiller protein 1.1
- CLR1.1
- Cold autoinflammatory syndrome 1 protein
背景信息 NACHT, LRR and PYD domains-containing protein 3 (NALP3), also called Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1 (CLR1.1), Cold autoinflammatory syndrome 1 protein (CIAS1), Cryopyrin, and PYRIN-containing APAF1-like protein 1 (PYPAF1) is a member of Nod-like receptors (NLR),and forms a caspase-1 activating molecular complex known as the inflammasome. The inflammasome activates IL-1β, the key component of inflammation and fever. NALP3 plays a role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 protein may function as an inducer of apoptosis and an activator of NF-κB signaling. NALP3 is expressed in blood leukocytespolymorphonuclear cells, osteoblasts, chondrocytes, non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). 产品信息 格式 Affinity Purified 控制 - K562 cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect NALP3 using this rabbit polyclonal antibody, Anti-NALP3 Antibody validated for use in western blotting & Immunofluorescence. 主要应用 - Western Blotting
应用说明 Immunofluorescence Analysis: 20 μg/mL from a representative lot detected NALP3 in K562 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human NALP3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - PYPAF1
- NLRP3
- CIAS1
- FCAS
- Cryopyrin
- C1orf7
- NALP3
纯化方法 Antigen Affinity purified UniProt编号 - Q96P20
产品使用声明 质量保证 Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected NALP3 in 15 µg of K562 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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