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merck millipore,默克密理博,06-1385,Anti-PDX1 (goat) Antibody
产品名称：Anti-PDX1 (goat) Antibody
产品型号：06-1385
Anti-PDX1 (goat) Antibody is a Goat Polyclonal Antibody for detection of PDX1 also known as pancreatic & duodenal homeobox 1, somatostatin transcription factor 1, Insulin promoter factor 1 & has been More>>
merck millipore,默克密理博,06-1385,Anti-PDX1 (goat) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC, WB Gt Serum Polyclonal Antibody 描述 产品目录编号 06-1385 描述 Anti-PDX1 (goat) Antibody Alternate Names - Islet/duodenum homeobox-1
- pancreatic and duodenal homeobox 1
- pancreatic-duodenal homeobox factor 1
- somatostatin transcription factor 1
- insulin promoter factor 1, homeodomain transcription factor
- Insulin promoter factor 1
- Somatostatin-transactivating factor 1
- Insulin upstream factor 1
- Glucose-sensitive factor
背景信息 Transcription factor PDX1, also known as pancreatic and duodenal homeobox 1, activates expression of the insulin and somatostatin genes. This protein is a key regulator of islet peptide hormone expression and also plays an essential role in pancreatic development. It has been shown to interact with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). This protein also interacts with the methyltransferase SETD7. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. 产品信息 格式 Serum 控制 - Mouse pancreatic β T-cell lysate
演示 Unpurified goat polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-PDX1 (goat) Antibody is a Goat Polyclonal Antibody for detection of PDX1 also known as pancreatic & duodenal homeobox 1, somatostatin transcription factor 1, Insulin promoter factor 1 & has been validated in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 1:400 dilution from a represenative lot detected PDX1 in normal human pancreas tissue. 生物信息 免疫原品种 Recombinant protein corresponding to the N-terminus of mouse PDX1. 表位 N-terminus 宿主 Goat 特异性 This antibody recognizes the N-terminus of PDX1. 品种反应性 HumanMouse Species Reactivity Note Demonstrated to react with human and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_032840
基因符号 - IPF-1
- GSF
- IDX-1
- STF-1
- IUF1
- PDX-1
- MODY4
- IPF1
- IUF-1
纯化方法 Unpurified UniProt编号 - P52946
UniProt汇总 FUNCTION: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
SUBUNIT STRUCTURE: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with the methyltransferase SETD7 By similarity. Interacts with SPOP.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
DEVELOPMENTAL STAGE: At 8.5 dpc, detected in the gut epithelium from which the pancreatic buds are formed. Transient expression in pancreatic ducts, endocrine and acinar cells. Down-regulated around 10.5 dpc when expression becomes restricted to differentiated beta-cells.
DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By Similarity).
The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By Similarity).
PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.
SEQUENCE SIMILARITIES: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.
Contains 1 homeobox DNA-binding domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse pancreatic β T-cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected PDX1 on 10 µg of mouse pancreatic β T-cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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