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merck millipore,默克密理博,ABE69,Anti-PTIP Antibody
产品名称：Anti-PTIP Antibody
产品型号：ABE69
Anti-PTIP Antibody is a Chicken Polyclonal Antibody for detection of PTIP also known as PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats & has be More>>
merck millipore,默克密理博,ABE69,Anti-PTIP Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Ch Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE69 描述 Anti-PTIP Antibody Alternate Names - PAX transcription activation domain interacting protein 1 like
- PAX interacting (with transcription-activation domain) protein 1
- PAX transactivation activation domain-interacting protein
- protein encoded by CAG trinucleotide repeats
背景信息 PAX transactivation activation domain-interacting protein (PTIP) is a ubiquitous nuclear protein composed of 5 tandem BRCA1 carboxyl-terminal (BRCT) domains. PTIP was initially identified as an interacting, transactivation protein that binds to the C-terminal end of Pax2. Since its discovery, studies have shown PTIP to bind several Pax proteins, playing a critical role in response to DNA damage. It also has activity as a phosphoserine/ phosphothreonine-specific binding module, and can discern ATM and ATR gamma irradiation induced phosphorylated substrates. PTIP is involved in early cellular development and is likely to have a role in cell proliferation as well. 产品信息 格式 Affinity Purified 控制 - A431 cell lysate
演示 Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PTIP Antibody is a Chicken Polyclonal Antibody for detection of PTIP also known as PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats & has been validated in WB, IHC & IF. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH (Patel, S., et al. (2007).
Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000).生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human PTIP. 宿主 Chicken 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_031375
Entrez基因汇总 This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq]. 基因符号 - CAGF29
- PAXIP1L
- PTIP
- PAXIP1
- TNRC2
- CAGF28
- PACIP1
纯化方法 Affinity Purified UniProt编号 - Q6ZW49
UniProt汇总 FUNCTION: Functions as a key component of the DNA damage response. Functions as phosphoserine or phosphothreonine-specific binding modules. Recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. May play a role in PAX2-dependent transcriptional regulation. Plays a role in early development, most probably in cell proliferation.
SUBUNIT STRUCTURE: Interacts with the C-terminal transactivation domain of PAX2 (By similarity). Interacts with C16orf53/PA1; the interaction is direct. Component of the MLL3/MLL4 complex, at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Some fraction of the complex contains MLL2 instead of MLL4 and is named MLL2/MLL3 complex.
SUBCELLULAR LOCATION: Nucleus membrane; Peripheral membrane protein; Matrix side (By similarity).
DOMAIN: The BRCT domains function as a single module and are necessary and sufficient for phospho-specific binding.
SEQUENCE SIMILARITIES: Contains 5 BRCT domains.
SEQUENCE CAUTION: The sequence AAB91434.1 differs from that shown. Reason: Frameshift at positions 609 and 628.
The sequence AAP21865.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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