merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1313,Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

  • merck millipore,默克密理博,MAB1313,Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

    产品名称：Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc
    产品型号：MAB1313
    Mouse anti-Human IgG4 Antibody, clone HP6025, Fc detects level of Human IgG4 & has been published & validated for use in ELISA, RIA & WB.

    merck millipore,默克密理博,MAB1313,Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

  • 产品介绍
  • merck millipore,默克密理博,MAB1313,Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1313
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid in 0.2 M phosphate buffer, 0.25 M NaCl, pH 7.6, with 0.1% sodium azide.
    应用
    应用 Mouse anti-Human IgG4 Antibody, clone HP6025, Fc detects level of Human IgG4 & has been published & validated for use in ELISA, RIA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 This antibody has been employed both as a capture antibody and as a detection antibody for human IgG subclass 4 in enzyme linked immunosorbent assays, radio-immunoassay and affinity immunoblots (Papadea et al., 1985; Hamilton, et al., 1987).
    生物信息
    表位 Fc fragment
    克隆 HP6025
    宿主 Mouse
    特异性 Human IgG subclass 4 Fc.

    ELISA Specificity:

    human IgG subclass 1 (0.48%)

    human IgG subclass 2 (0.08%)

    human IgG subclass 3 (0.18%)

    human IgG subclass 4 (100%)
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004001.3
    • NM_001002273.1
    • NM_001002274.1
    • NM_001002275.1
    基因符号
    • FCGR2
    • FCGR2B
    • CDw32
    • CD32B
    • IGFR2
    • CD32
    • Fc-gamma-RIIb
    • FCG2
    • FcRII-b
    UniProt编号
    • P31994
    UniProt汇总 FUNCTION: SwissProt: P31994 # Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
    SIZE: 310 amino acids; 34044 Da
    SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
    DOMAIN: SwissProt: P31994 Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.DISEASE:SwissProt: P31994 # A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
    SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at +4°C. DO NOT FREEZE.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,MAB1313,Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

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